Nate is now a tropical depression, but brought flooding and power outages to those along the U.S. Gulf Coast who were in its path.
Nate's maximum sustained winds have decreased to 35 mph as it closes in on Birmingham, Alabama, according to the National Hurricane Center (NHC).
It was a Category 1 hurricane when it came ashore near Biloxi, Mississippi early Sunday.
Nate's center is expected to continue moving inland across the South, the Tennessee Valley and the central Appalachian Mountains into Monday.
Slamming Mississippi and Alabama, Tropical Storm Nate, which made two landfalls as a hurricane, continues its destructive pathas a tropical storm.
It's weakening as it moves northward and away from the U.S. Gulf Coast.
The National Hurricane Center in Miami says Nate's maximum sustained winds have decreased to near 45 mph (75 kph) with higher gusts. The storm is expected to continue to rapidly weaken as it moves farther inland across the Deep South, Tennessee Valley and central Appalachian mountains. Through Monday, those areas can expect at least 3 to 6 inches of rain.
More than 100,000 residents in Mississippi and Alabama are without power.
Alabama Power Co. said about 59,000 customers lost their electricity in the state. About 53,000 of those were in the Mobile area.
Hurricane Nate has made landfall near the mouth of the Mississippi River as a Category 1 storm with winds of 85 mph.
The storm is currently located about 100 miles south of Biloxi, Mississippi, and is moving north at 20 mph, according to the National Hurricane Center (NHC).
The center of Hurricane Nate is quickly approaching the mouth of the Mississippi River, moving north northwest at 23 mph, according to the National Hurricane Center (NHC).
NHC said Nate is expected to bring life-threatening storm surge flooding of 7 to 11 feet to portions of southeastern Louisiana and areas along the Mississippi coast.
Currently, the storm is packing maximum sustained winds of 90 mph and forecasters say Nate still has time to reach Category 2 strength before it makes landfall.
Gulf Coast residents scrambled to finalize storm preparations as Hurricane Nate raced swiftly over the central Gulf of Mexico on Saturday, gaining added strength as forecasters said it would smash into the U.S. coast during the night.
Louisiana's governor urged his state's residents to take Nate seriously, saying the storm "has the potential to do a lot of damage."
"No one should take this storm lightly. It has already claimed the lives of at least 20 people," Gov. John Bel Edwards said Friday. "We do want people to be very, very cautious and to not take this storm for granted."
The Associated Press contributed to this report.
Yet another major storm is brewing in the waters near the North American continent. Tropical Storm Nate is picking up steam in the Carribean Sea just north of Honduras and will make landfall on the northern Gulf Coast as a tropical storm or a hurricane either Saturday night or Sunday morning, reports the Weather Channel.
Nate will bring heavy rains to the U.S. Gulf Coast and to sections of Appalachia. Rains could also stretch as far as the northeastern United States.
Nate will makes its closest pass to Mexico near the city of Cancún and the island of the Cozumel. Storm warnings are in effect for both areas. Elsewhere in the country, the Yucatan peninsula is ramping up emergency measures.