A crash involving dozens of vehicles on I-95 in Baltimore sent nine patients to R Adams Cowley Shock Trauma Center on Saturday morning.
Medical officials said all patients, as of 9:30 a.m., were being triaged.
According to transit officials, at least one person was killed after a fuel tanker went over a jersey barrier and caught fire.
The crash happened near the exit for Washington Boulevard.
Maryland Transportation Authority (MDTA) officials confirm 55 vehicles were involved, 40 of which were still being cleared from the roadway by 11:45 a.m.
Mayor Catherine Pugh expressed concern and offered her condolences to those affected by the crash.
Pugh posted her statement to Twitter.
Traffic on southbound I-95 was detoured to MD 295 and I-395 until around 1:30 p.m., when all southbound lanes re-opened.
Lanes on northbound I-95 remained blocked past Caton Avenue, with all traffic diverted to eastbound I-695 as the crash investigation and cleanup efforts continued.
MDTA officials say it was one of two fatal accidents on I-95; an earlier crash took place on I-95 northbound near Eastern Avenue around 5 a.m.
(The Sinclair Broadcast Group contributed to this report)