Philippine Vice President, Leni Robredo, announced Sunday that she will resign from her Cabinet post.
Robredo, a human rights lawyer, said she was resigning due to "major differences in principles and values" with President Rodrigo Duterte.
She is expected to formally resign as housing secretary on Monday but plans to continue serving as vice president of the country, despite her differences with Duterte.
The Philippines elects presidents and vice presidents separately, so often they are from opposing parties. There has been talk of Duterte plotting to have her removed from the vice president position.
"I will not allow the vice presidency to be stolen. I will not allow the will of the people to be thwarted," Robredo told reporters. "I will continue to serve the Filipino family and fulfill their dream for a better life."
Robredo is the second official to resign from office in less than a week.
Robredo previously said she's opposed to Duterte's drug killings policy, his plan to reimpose the death penalty and "sexual attacks against women."
Duterte's plan to kill the country's suspected drug dealers and users has raised eyebrows among other foreign leadership. The United States, the European Parliament and the International Criminal Court have all criticized Duterte's tactics.
However, Duterte announced Saturday that President-elect Donald Trump endorsed his anti-drug campaign that has left at least 4,500 Filipinos dead, according to the Washington Post. The comments, which have not been confirmed by the Trump camp, could mean a shift in U.S.-Philippine relations.
As for Robredo, she said Duterte barred her from attending Cabinet meetings, making it impossible for her to do her job.
Robredo added that she is trying to ignore warnings of a plot to steal her position as vice president so she can focus on her work.
The Associated Press contributed to this report.