Isaiah Pead, who was most recently a running back for the Miami Dolphins, lost part of his leg in a car accident, according to his college coach at Cincinnati.
Pead, was in a car accident last weekend that left him in critical condition.
Tommy Tuberville, Pead's college coach said on his weekly radio show that Pead will "never play again, obviously. It's just devastating," according to the Cincinnati Enquirer.
Pead had played three games for the Miami Dolphins this season. He spent the majority of his career with the St. Louis Rams, playing 27 games.
Reports say Pead was driving his 2011 Cadillac CTS sedan on Interstate 670 near Columbus, Ohio, when he lost control of the vehicle.
Police say his car ran off the highway and went through the metal guardrail, flying into the air before hitting several trees. The car stopped nearly 100 feet from the highway.
Pead, who was not wearing a seatbelt according to police, was ejected from the car. Authorities say speed may have been a factor.
Recording artist Reuben X posted a picture of Pead smiling.