Both teams have had lengthy World Series droughts. The Indians haven't won since 1948. The Cubs haven't even been to the Fall Classic since 1945, and they haven't won since 1908.
While all that baseball is going on, the Cleveland Cavaliers kick off the defense of their NBA championship on the same night. USA Today reports the NBA even rescheduled the Cavs ring ceremony so fans didn't have to miss the Indians game.
This could get hectic in the city. Both the Quicken Loans Arena (at left, where the Cavs play) and Progressive Field (to the right, where the Indians play) share a parking lot.
On the West Coast, the Golden State Warriors will start their run for a championship, now with superstar Kevin Durant on the squad, playing against the San Antonio Spurs. The Utah Jazz and Portland Trail Blazers also play tonight.