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A framegrab of the plume of smoke after an explosion at a BASF chemical facility in Germany. (AP Video framegrab)

An explosion at the world's biggest chemical producer has turned deadly in Germany

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An explosion at a facility belonging to BASF, the world's largest chemical firm, killed at least two people and injured six others on Monday in Germany. Hours after the explosion, two people were still missing.

The explosion occurred at a harbor in Ludwigshafen. The facility is used to unload flammable liquids and liquified gas. 

Work on a pipeline led to the explosion, according to a BASF statement. 

An explosion at the world's biggest chemical producer has turned deadly in Germany

Here's how the smoke from the explosion looked from afar. Locals were urged to stay inside and keep their doors and windows closed, but the Rheinpfalz newspaper reported some had breathing problems.

The death toll is expected to rise, The Independent reports.

This tweet captures the moment of the explosion.

Here's an aerial view.

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